The average yearly salary for Public Health Informatics in San Luis Obispo, California is $58,603. If you are just beginning to work a new job as a Public Health Informatics in San Luis Obispo, California, you could earn a starting pay rate of $48,261 annually. As is true for most jobs and careers, you can expect your hourly pay rate or salary to increase as you gain experience and the longer you are employed with the same employer. In San Luis Obispo you could potentially make an average income of around $68,945 after several years on the job with increased wages. When pursuing your career of choice, you should compare salaries of similar professions and factor in variables such as health benefits and potential for raises and promotions over time.